Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
psmB1psmB proteasome, subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (197 aa)    
Predicted Functional Partners:
psmA
psmA proteasome, subunit alpha (EC 3.4.99.46); Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.917
psmB2
psmB-like proteasome, subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
  
 
0.906
PAB2200
Hypothetical protein.
       0.906
pan
26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
  
 0.874
glpk
glpK glycerol kinase (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
   
 0.791
thrC-2
thrC threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
     0.726
hemU-2
hemU iron (III) ABC transporter, permease protein.
       0.717
hemV-2
hemV-2 iron (III) ABC transporter, ATP-binding protein.
       0.717
PAB1113
Hypothetical protein.
       0.680
PAB1919
Transcription regulator protein, putative, Mov34/MPN/PAD-1 family.
  
 0.668
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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