close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAB2248bioY biotin biosynthesis protein. (163 aa)    
Predicted Functional Partners:
PAB2261
Cobalt transport protein, cbiQ family.
 
 0.991
PAB2260
ABC transporter, ATP-binding protein, substrate unknown; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
 
 
 0.967
PAB0249
ABC ABC-type transport system, ATPase component, substrate unknown; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
 
 
 0.955
birA
Biotin-(acetyl-coA carboxylase) ligase.
 
   
 0.856
birA-like
birA-like biotin operon repressor/biotin--[acetyl coA carboxylase] ligase homolog.
 
   
 0.845
nB
panB 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
     
 0.746
PAB1771
mmdC methylmalonyl-coA decarboxylase gamma chain.
 
   
 0.552
PAB2198
Hypothetical protein.
      
 0.526
tgtA
Queuine-archaeosine tRNA ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
     0.515
mmdA
mmdA methylmalonyl-coA decarboxylase, alpha chain.
 
     0.470
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.