STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcAHypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (469 aa)    
Predicted Functional Partners:
ppsA
ppsA probable phosphoenolpyruvate synthase (pyruvate,water dikinase) (PEP synthase) (EC 2.7.9.2); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
  
  
 0.929
pckG
pckA phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.919
eno-like
Eno-like enolase related.
  
  
  0.912
PAB1441
Pyk pyruvate kinase (EC 2.7.1.40) (PK); Belongs to the pyruvate kinase family.
     
 0.903
eno
Eno enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase) (EC 4.2.1.11); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
PAB1772
mmdB methylmalonyl-coA decarboxylase, beta chain.
     
  0.900
PAB1389
fdhA formate dehydrogenase, alpha subunit.
     
  0.800
PAB1390
Oxidoreductase iron-sulfur protein.
     
  0.800
fdhA-like
Formate dehydrogenase alpha subunit.
     
  0.800
nadB
nadB L-aspartate oxidase (EC 1.4.3.16) (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate.
       0.788
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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