STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCdp2/polC intein containing DNA polymerase II large subunit (EC 2.7.7.7); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity). (1455 aa)    
Predicted Functional Partners:
polB
dp1/polB intein containing DNA polymerase II small subunit (2.7.7.7); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family.
 
 
 
 0.999
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non- specific cleavage.
 
 
 
 0.975
cdc6
Cdc6/orc1 cell division control protein 6; Involved in regulation of DNA replication (By similarity). Binds specifically to the oriC region.
 
   
 0.966
PAB0252
Predicted RNA-binding protein.
  
     0.674
PAB0082
Queuine tRNA-ribosyltransferase.
  
   
 0.667
PAB0406
Predicted RNA-binding protein.
  
     0.661
cdc21
MCM inteins containing helicase, minichromosome maintenance protein; Belongs to the MCM family.
 
   
 0.658
nac
Transcription factor homologous to nascent polypeptide-associated complex NAC; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.
  
     0.655
radA
radA DNA repair protein rad51 : DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (By similarity).
 
   
 0.648
recJ-like
recJ-like single-stranded exonuclease recJ homolog.
 
     0.638
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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