STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nikMNCobalamin biosynthesis protein, CbiM family; Part of the energy-coupling factor (ECF) transporter complex NikMNQO involved in nickel import. The complex confers nickel uptake upon expression in E.coli; can also transport cobalt with a very low affinity. (347 aa)    
Predicted Functional Partners:
cbiQ1
Cobalt ABC transporter, permease protein CbiQ-1; Part of the energy-coupling factor (ECF) transporter complex NikMNQO involved in nickel import. The complex confers nickel uptake upon expression in E.coli; can also transport cobalt with a very low affinity.
 
 0.999
cbiO1
Cobalt ABC transporter, ATP-binding protein CbiO-1; Part of the energy-coupling factor (ECF) transporter complex NikMNQO involved in nickel import. The complex confers nickel uptake upon expression in E.coli; can also transport cobalt with a very low affinity. Presumably responsible for energy coupling to the transport system.
 
  
 0.998
cbiQ2
Cobalt ABC transporter, permease protein CbiQ-2; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity; Belongs to the CbiQ family.
 
 
 0.987
cbiN
Cobalt transport protein CbiN; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. A Cbi(MN) fusion protein has about 70% import capacity, but the holo-Cbi(MN)QO complex cannot be isolated, suggesting CbiN may destabilize it.
 
 
 0.983
cbiO2
Cobalt ABC transporter, ATP-binding protein CbiO-2; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. Presumably responsible for energy coupling to the transport system.
 
 
 0.978
cbiM
Cobalamin biosynthesis protein, CbiM family; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. The complex confers cobalt uptake upon expression in E.coli; can also transport nickel with a very low affinity. A Cbi(MN) fusion protein has about 70% import capacity, but the holo-Cbi(MN)QO complex cannot be isolated, suggesting CbiN may destabilize it.
  
  
 
0.926
ADE87081.1
Conserved hypothetical protein.
    
 0.845
cbiQ3
Cobalt ABC transporter, permease protein CbiQ-3; Probably involved in biotin uptake, although complementation experiments in E.coli do not indicate a clear role.
  
  
 0.715
cobK
Precorrin-6x reductase; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
  
  
 0.630
cobL
precorrin-6Y C5,15-methyltransferase (decarboxylating).
  
  
 0.562
Your Current Organism:
Rhodobacter capsulatus
NCBI taxonomy Id: 272942
Other names: R. capsulatus SB 1003, Rhodobacter capsulatus SB 1003
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