STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (728 aa)    
Predicted Functional Partners:
RSP_0782
Ppx/GppA phosphatase; IMG reference gene:2512955809; PFAM: Ppx/GppA phosphatase family; TIGRFAM: exopolyphosphatase.
 
  
 0.976
RSP_0013
Polyphosphate kinase 2, PA0141 family; IMG reference gene:2512954995; PFAM: Polyphosphate kinase 2 (PPK2); TIGRFAM: polyphosphate kinase 2, PA0141 family.
 
  
 0.963
RSP_0766
Polyphosphate kinase 2, PA0141 family; IMG reference gene:2512955796; PFAM: Polyphosphate kinase 2 (PPK2); TIGRFAM: polyphosphate kinase 2, PA0141 family.
 
  
 0.953
RSP_2771
Putative Exopolyphosphatase; IMG reference gene:2512954721; PFAM: Ppx/GppA phosphatase family.
 
  
 0.932
RSP_2307
Putative manganese-dependent inorganic pyrophosphatase; IMG reference gene:2512954241; PFAM: DHH family; DHHA2 domain.
   
 
  0.900
RSP_0780
ATPase involved in DNA replication initiation; IMG reference gene:2512955807; PFAM: Bacterial dnaA protein; Belongs to the DnaA family.
  
  
 0.780
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
   
 0.763
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.674
ccr
crotonyl-CoA carboxylase/reductase; Catalyzes the NADPH-dependent reductive carboxylation of crotonyl-CoA ((2E)-butenoyl-CoA) to (2S)-ethylmalonyl-CoA, in the presence of CO2. This is a key reaction in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is also able to accept acryloyl-CoA as an alternative substrate, yielding (2S)- methylmalonyl-CoA. To a lesser extent, when CO2 is absent, the enzyme also catalyzes the reduction of crotonyl-CoA to butanoyl-CoA.
      
 0.673
perM
Lipocalin-related protein and Bos/Can/Equ allergen; IMG reference gene:2512955806; PFAM: Domain of unknown function DUF20; truncated by 17 aa.
       0.670
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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