node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSP_1978 | RSP_3474 | RSP_1978 | RSP_3474 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | 0.729 |
RSP_1978 | clpB | RSP_1978 | RSP_1408 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.729 |
RSP_1978 | dnaK | RSP_1978 | RSP_1173 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Heat shock protein (Hsp70, DnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
RSP_1978 | groEL | RSP_1978 | RSP_2311 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.711 |
RSP_1978 | groEL-2 | RSP_1978 | RSP_3615 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Thermosome subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.711 |
RSP_1978 | groEL3 | RSP_1978 | RSP_2798 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Putative chaperonin groEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.711 |
RSP_1978 | groES | RSP_1978 | RSP_2310 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Chaperonin Cpn10 (GroES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.708 |
RSP_1978 | grpE | RSP_1978 | RSP_1219 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.961 |
RSP_1978 | hrcA | RSP_1978 | RSP_1220 | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.893 |
RSP_3474 | RSP_1978 | RSP_3474 | RSP_1978 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | 0.729 |
RSP_3474 | dnaJ | RSP_3474 | RSP_1172 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Chaperone, DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.755 |
RSP_3474 | dnaK | RSP_3474 | RSP_1173 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Heat shock protein (Hsp70, DnaK); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.963 |
RSP_3474 | groEL | RSP_3474 | RSP_2311 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.489 |
RSP_3474 | groEL-2 | RSP_3474 | RSP_3615 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Thermosome subunit; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.495 |
RSP_3474 | groEL3 | RSP_3474 | RSP_2798 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Putative chaperonin groEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. Belongs to the chaperonin (HSP60) family. | 0.495 |
RSP_3474 | groES | RSP_3474 | RSP_2310 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Chaperonin Cpn10 (GroES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.696 |
RSP_3474 | grpE | RSP_3474 | RSP_1219 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.894 |
RSP_3474 | hrcA | RSP_3474 | RSP_1220 | Type VI secretion ATPase, ClpV1 family; IMG reference gene:2512956984; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: type VI secretion ATPase, ClpV1 family; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.618 |
clpB | RSP_1978 | RSP_1408 | RSP_1978 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Molecular chaperone, DnaJ family; IMG reference gene:2512953894; PFAM: DnaJ domain. | 0.729 |
clpB | dnaJ | RSP_1408 | RSP_1172 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone, DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.902 |