| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DnaE | RSP_1458 | RSP_1123 | RSP_1458 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Putative DNA repair enzyme; IMG reference gene:2512953350; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family. | 0.918 |
| DnaE | dinB | RSP_1123 | RSP_1400 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.881 |
| DnaE | lexA | RSP_1123 | RSP_1997 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the direct repeat sequence 5'-GTT-N(7)-GTTC-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.891 |
| DnaE | recA | RSP_1123 | RSP_0452 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.865 |
| DnaE | recN | RSP_1123 | RSP_2118 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.866 |
| DnaE | ruvA | RSP_1123 | RSP_0555 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.466 |
| DnaE | ruvC | RSP_1123 | RSP_0556 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. | 0.771 |
| DnaE | uvrA | RSP_1123 | RSP_2966 | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.780 |
| RSP_1458 | DnaE | RSP_1458 | RSP_1123 | Putative DNA repair enzyme; IMG reference gene:2512953350; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family. | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.918 |
| RSP_1458 | lexA | RSP_1458 | RSP_1997 | Putative DNA repair enzyme; IMG reference gene:2512953350; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the direct repeat sequence 5'-GTT-N(7)-GTTC-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.818 |
| RSP_1458 | recA | RSP_1458 | RSP_0452 | Putative DNA repair enzyme; IMG reference gene:2512953350; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.826 |
| RSP_1458 | recN | RSP_1458 | RSP_2118 | Putative DNA repair enzyme; IMG reference gene:2512953350; PFAM: impB/mucB/samB family C-terminal; impB/mucB/samB family. | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.439 |
| RSP_1468 | lexA | RSP_1468 | RSP_1997 | Site-specific DNA-methyltransferase; IMG reference gene:2512953361; PFAM: DNA methylase; Belongs to the N(4)/N(6)-methyltransferase family. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the direct repeat sequence 5'-GTT-N(7)-GTTC-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.944 |
| dinB | DnaE | RSP_1400 | RSP_1123 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.881 |
| dinB | lexA | RSP_1400 | RSP_1997 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the direct repeat sequence 5'-GTT-N(7)-GTTC-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.983 |
| dinB | recA | RSP_1400 | RSP_0452 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.914 |
| dinB | recN | RSP_1400 | RSP_2118 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.555 |
| dinB | ruvA | RSP_1400 | RSP_0555 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.406 |
| dinB | uvrA | RSP_1400 | RSP_2966 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.741 |
| lexA | DnaE | RSP_1997 | RSP_1123 | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the direct repeat sequence 5'-GTT-N(7)-GTTC-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.891 |
