node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSP_2346 | cspA | RSP_2346 | RSP_2024 | IMG reference gene:2512954282; PFAM: 'Cold-shock' DNA-binding domain. | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | 0.632 |
RSP_2346 | rplS | RSP_2346 | RSP_1044 | IMG reference gene:2512954282; PFAM: 'Cold-shock' DNA-binding domain. | LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.532 |
RSP_2346 | rplT | RSP_2346 | RSP_1764 | IMG reference gene:2512954282; PFAM: 'Cold-shock' DNA-binding domain. | LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.555 |
cspA | RSP_2346 | RSP_2024 | RSP_2346 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | IMG reference gene:2512954282; PFAM: 'Cold-shock' DNA-binding domain. | 0.632 |
cspA | grpE | RSP_2024 | RSP_1219 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.488 |
cspA | hfq | RSP_2024 | RSP_2843 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.684 |
cspA | hrcA | RSP_2024 | RSP_1220 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.624 |
cspA | ksgA | RSP_2024 | RSP_2905 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.651 |
cspA | rhlE | RSP_2024 | RSP_2536 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | ATP-dependent helicase, DEAD-box; IMG reference gene:2512954480; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. | 0.768 |
cspA | rne | RSP_2024 | RSP_2131 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | RNAse E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 0.486 |
cspA | rplS | RSP_2024 | RSP_1044 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.532 |
cspA | rplT | RSP_2024 | RSP_1764 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | LSU ribosomal protein L20P; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.555 |
cspA | tolB | RSP_2024 | RSP_0669 | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | Translocation protein TolB precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. | 0.531 |
grpE | cspA | RSP_1219 | RSP_2024 | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | 0.488 |
grpE | hrcA | RSP_1219 | RSP_1220 | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.994 |
grpE | ksgA | RSP_1219 | RSP_2905 | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.457 |
grpE | rplS | RSP_1219 | RSP_1044 | Putative chaperone protein GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | LSU ribosomal protein L19P; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.425 |
hfq | cspA | RSP_2843 | RSP_2024 | RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | IMG reference gene:2512953942; PFAM: 'Cold-shock' DNA-binding domain. | 0.684 |
hfq | hrcA | RSP_2843 | RSP_1220 | RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.491 |
hfq | ksgA | RSP_2843 | RSP_2905 | RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.517 |