Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RSP_2124Methionine synthase I; IMG reference gene:2512954048; PFAM: Homocysteine S-methyltransferase. (335 aa)    
Predicted Functional Partners:
RSP_2768
Pterin binding enzyme; IMG reference gene:2512954718; PFAM: Pterin binding enzyme.
 
 0.998
RSP_3346
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 0.997
mtbC
Putative dimethylamine corrinoid protein; IMG reference gene:2512954046; PFAM: B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain.
    0.984
RSP_2769
Putative 5,10-methylenetetrahydrofolate reductase; IMG reference gene:2512954719; truncated by 14 aa.
 
 
 0.975
metF
5,10-methylenetetrahydrofolate reductase (NAD(P)); IMG reference gene:2512954095; PFAM: Methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase, prokaryotic form; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.973
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 
 0.946
RSP_2917
Putative cystathionine gamma-synthase beta-lyase; IMG reference gene:2512954879; PFAM: Cys/Met metabolism PLP-dependent enzyme.
  
 
 0.944
RSP_3566
Dimethylglycine dehydrogenase; IMG reference gene:2512957076; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; FAD dependent oxidoreductase; Belongs to the GcvT family.
 
 
 0.944
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.933
RSP_2431
O-acetylhomoserine sulfhydrylase; IMG reference gene:2512954375; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase.
  
 
 0.931
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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