Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (884 aa)    
Predicted Functional Partners:
RSP_0621
Putative DNA helicase; IMG reference gene:2512955637; PFAM: Helicase conserved C-terminal domain; UvrD/REP helicase; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family.
  
 0.971
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.949
RSP_2177
DNA protecting protein DprA; IMG reference gene:2512954100; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA.
   
 0.938
rpoC
DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.911
recQ
ATP-dependent DNA helicase RecQ; IMG reference gene:2512956406; PFAM: Helicase conserved C-terminal domain; RQC domain; HRDC domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecQ; ATP-dependent DNA helicase, RecQ family.
  
 0.894
dnaE
DNA polymerase III, alpha subunit; IMG reference gene:2512957063; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; TIGRFAM: DNA-directed DNA polymerase III (polc).
  
  
 0.878
recG
ATP-dependent DNA helicase RecG; IMG reference gene:2512954567; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecG.
 
  
 0.868
rpoB
DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.850
recN
DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA.
  
  
 0.846
pyrB
IMG reference gene:2512956040; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
    
 0.832
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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