| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MeaA | RSP_0029 | RSP_0961 | RSP_0029 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | 0.759 |
| MeaA | argK | RSP_0961 | RSP_2015 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | IMG reference gene:2512953931; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase. | 0.999 |
| MeaA | epi | RSP_0961 | RSP_0812 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | methylmalonyl-CoA epimerase; Promiscuous isomerase that catalyzes epimerization of both ethylmalonyl-CoA and methylmalonyl-CoA. Has thus a dual role in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.998 |
| MeaA | mcmA | RSP_0961 | RSP_2192 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | methylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- methylmalonyl-CoA to succinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.992 |
| MeaA | mdh | RSP_0961 | RSP_0968 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.432 |
| MeaA | pycA | RSP_0961 | RSP_2090 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. | 0.495 |
| MeaA | sucC | RSP_0961 | RSP_0967 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.493 |
| MeaA | sucD | RSP_0961 | RSP_0966 | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | Succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.533 |
| RSP_0029 | MeaA | RSP_0029 | RSP_0961 | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | 0.759 |
| RSP_0029 | argK | RSP_0029 | RSP_2015 | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | IMG reference gene:2512953931; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase. | 0.435 |
| RSP_0029 | mcmA | RSP_0029 | RSP_2192 | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | methylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- methylmalonyl-CoA to succinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.951 |
| RSP_0029 | sucC | RSP_0029 | RSP_0967 | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.980 |
| RSP_0029 | sucD | RSP_0029 | RSP_0966 | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | Succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.969 |
| RSP_1041 | epi | RSP_1041 | RSP_0812 | malonyl-CoA synthase; IMG reference gene:2512956081; PFAM: AMP-binding enzyme. | methylmalonyl-CoA epimerase; Promiscuous isomerase that catalyzes epimerization of both ethylmalonyl-CoA and methylmalonyl-CoA. Has thus a dual role in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.903 |
| RSP_1041 | mcmA | RSP_1041 | RSP_2192 | malonyl-CoA synthase; IMG reference gene:2512956081; PFAM: AMP-binding enzyme. | methylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- methylmalonyl-CoA to succinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.907 |
| argK | MeaA | RSP_2015 | RSP_0961 | IMG reference gene:2512953931; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase. | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | 0.999 |
| argK | RSP_0029 | RSP_2015 | RSP_0029 | IMG reference gene:2512953931; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase. | IMG reference gene:2512955012; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain; Citrate lyase, alpha subunit (CitF); TIGRFAM: succinate CoA transferases. | 0.435 |
| argK | epi | RSP_2015 | RSP_0812 | IMG reference gene:2512953931; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase. | methylmalonyl-CoA epimerase; Promiscuous isomerase that catalyzes epimerization of both ethylmalonyl-CoA and methylmalonyl-CoA. Has thus a dual role in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.800 |
| argK | mcmA | RSP_2015 | RSP_2192 | IMG reference gene:2512953931; PFAM: ArgK protein; TIGRFAM: LAO/AO transport system ATPase. | methylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- methylmalonyl-CoA to succinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | 0.999 |
| epi | MeaA | RSP_0812 | RSP_0961 | methylmalonyl-CoA epimerase; Promiscuous isomerase that catalyzes epimerization of both ethylmalonyl-CoA and methylmalonyl-CoA. Has thus a dual role in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. | (R)-ethylmalonyl-CoA mutase; Radical enzyme that catalyzes the transformation of (2R)- ethylmalonyl-CoA to (2S)-methylsuccinyl-CoA. Is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation required for R.sphaeroides growth on acetate as sole carbon source. Is highly specific for its substrate, ethylmalonyl-CoA, and accepts methylmalonyl-CoA only at 0.2% relative activity. | 0.998 |
