node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PurD | RSP_3566 | RSP_1847 | RSP_3566 | Phosphoribosylamine--glycine ligase; IMG reference gene:2512953756; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Dimethylglycine dehydrogenase; IMG reference gene:2512957076; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; FAD dependent oxidoreductase; Belongs to the GcvT family. | 0.488 |
PurD | SHMT | RSP_1847 | RSP_0823 | Phosphoribosylamine--glycine ligase; IMG reference gene:2512953756; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Serine hydroxymethyltransferase protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.918 |
PurD | gcvH | RSP_1847 | RSP_2194 | Phosphoribosylamine--glycine ligase; IMG reference gene:2512953756; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Glycine cleavage system H protein (predicted); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.509 |
PurD | gcvP | RSP_1847 | RSP_2195 | Phosphoribosylamine--glycine ligase; IMG reference gene:2512953756; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.949 |
PurD | soxA | RSP_1847 | RSP_2689 | Phosphoribosylamine--glycine ligase; IMG reference gene:2512953756; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family. | Putative sarcosine oxidase, alpha subunit; IMG reference gene:2512954634; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form; Belongs to the GcvT family. | 0.402 |
RSP_0962 | RSP_2968 | RSP_0962 | RSP_2968 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase; IMG reference gene:2512954934; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | 0.910 |
RSP_0962 | RSP_3566 | RSP_0962 | RSP_3566 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Dimethylglycine dehydrogenase; IMG reference gene:2512957076; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; FAD dependent oxidoreductase; Belongs to the GcvT family. | 0.619 |
RSP_0962 | SHMT | RSP_0962 | RSP_0823 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
RSP_0962 | gcvH | RSP_0962 | RSP_2194 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein (predicted); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.988 |
RSP_0962 | gcvP | RSP_0962 | RSP_2195 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.954 |
RSP_0962 | gcvT | RSP_0962 | RSP_2193 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Putative aminomethyltransferase, tetrahydrofolate dependent; IMG reference gene:2512954121; PFAM: Aminomethyltransferase folate-binding domain; Glycine cleavage T-protein C-terminal barrel domain; TIGRFAM: glycine cleavage system T protein. | 0.963 |
RSP_0962 | soxA | RSP_0962 | RSP_2689 | Dihydrolipoamide dehydrogenase; IMG reference gene:2512955999; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Putative sarcosine oxidase, alpha subunit; IMG reference gene:2512954634; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form; Belongs to the GcvT family. | 0.826 |
RSP_1448 | RSP_2302 | RSP_1448 | RSP_2302 | L-threonine aldolase; IMG reference gene:2512953339; PFAM: Beta-eliminating lyase. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.900 |
RSP_1448 | SHMT | RSP_1448 | RSP_0823 | L-threonine aldolase; IMG reference gene:2512953339; PFAM: Beta-eliminating lyase. | Serine hydroxymethyltransferase protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
RSP_1448 | gcvP | RSP_1448 | RSP_2195 | L-threonine aldolase; IMG reference gene:2512953339; PFAM: Beta-eliminating lyase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.951 |
RSP_1448 | soxA | RSP_1448 | RSP_2689 | L-threonine aldolase; IMG reference gene:2512953339; PFAM: Beta-eliminating lyase. | Putative sarcosine oxidase, alpha subunit; IMG reference gene:2512954634; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form; Belongs to the GcvT family. | 0.922 |
RSP_2302 | RSP_1448 | RSP_2302 | RSP_1448 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | L-threonine aldolase; IMG reference gene:2512953339; PFAM: Beta-eliminating lyase. | 0.900 |
RSP_2302 | SHMT | RSP_2302 | RSP_0823 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Serine hydroxymethyltransferase protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |
RSP_2302 | gcvP | RSP_2302 | RSP_2195 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.951 |
RSP_2302 | soxA | RSP_2302 | RSP_2689 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | Putative sarcosine oxidase, alpha subunit; IMG reference gene:2512954634; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: sarcosine oxidase, alpha subunit family, heterotetrameric form; Belongs to the GcvT family. | 0.931 |