Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gfaGlutathione-dependent formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (196 aa)    
Predicted Functional Partners:
adhI
Alcohol dehydrogenase class III; Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short- chain aliphatic alcohols; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
   
 0.996
xoxF
Putative pqq dehydrogenase protein; IMG reference gene:2512954521; PFAM: Pyrrolo-quinoline quinone coenzyme N-terminus; Pyrrolo-quinoline quinone coenzyme C-terminus; PQQ enzyme repeat; TIGRFAM: PQQ-dependent dehydrogenase, methanol/ethanol family.
 
  
 0.990
fghA
S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.
  
 0.968
cycB
Cytochrome c553i; IMG reference gene:2512954522; TIGRFAM: c-type cytochrome, methanol metabolism-related.
 
   
 0.957
xoxJ
Amino acid ABC transporter substrate-binding protein, PAAT family; IMG reference gene:2512954523; PFAM: Bacterial extracellular solute-binding proteins, family 3; TIGRFAM: quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein.
 
   
 0.935
cycI
Isocytochrome c2; IMG reference gene:2512954520; PFAM: Cytochrome c.
     
 0.839
RSP_2588
Hypothetical protein; IMG reference gene:2512954531.
 
    0.707
RSP_2574
IMG reference gene:2512954517; PFAM: Protein of unknown function (DUF2380).
 
     0.584
RSP_2595
Hypothetical protein; IMG reference gene:2512954538.
 
     0.579
RSP_2581
Rhodanese; IMG reference gene:2512954524; PFAM: Rhodanese-like domain; TIGRFAM: PQQ-dependent catabolism-associated CXXCW motif protein.
 
     0.516
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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