STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (704 aa)    
Predicted Functional Partners:
recG
ATP-dependent DNA helicase RecG; IMG reference gene:2512954567; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase RecG.
 
  
 0.929
lig2
DNA ligase; IMG reference gene:2512954357; PFAM: ATP dependent DNA ligase domain; DNA ligase N terminus; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA ligase, ATP-dependent, PP_1105 family.
    
 0.924
RSP_0621
Putative DNA helicase; IMG reference gene:2512955637; PFAM: Helicase conserved C-terminal domain; UvrD/REP helicase; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family.
  
 
 0.865
leuS
leucyl-tRNA synthetase; IMG reference gene:2512955869; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, eubacterial and mitochondrial family; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.859
RSP_2092
ATP-dependent DNA helicase, Rep family; IMG reference gene:2512954015; PFAM: UvrD/REP helicase.
 
  
 0.833
ruvC
Holliday junction endonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
   
  
 0.765
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
  
 0.739
RSP_0455
IMG reference gene:2512955465; PFAM: NOL1/NOP2/sun family; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.726
RSP_6147
rRNA methyltransferase RsmB; IMG reference gene:2512956147; PFAM: NOL1/NOP2/sun family; NusB family; truncated by 11 aa; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.722
RSP_3756
DNA/RNA helicase, superfamily I; IMG reference gene:2512957288; PFAM: UvrD/REP helicase; extended by 11 aa.
  
  
 0.694
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.