STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tetRTranscriptional regulator, TetR family; IMG reference gene:2512954813; PFAM: Bacterial regulatory proteins, tetR family; extended by 11 aa. (200 aa)    
Predicted Functional Partners:
acuR
Transcriptional regulator, TetR family; A transcriptional repressor for its operon. Probably binds to 2 operator sequences in the promoter.
   
  
 0.874
acuI
Putative Zn-dependent oxidoreductase; Catalyzes the NADPH-dependent reduction of acrylyl-CoA to propanoyl-CoA. Is essential for growth with 3-hydroxypropanoate as a sole carbon source. Restores acrylate resistance when expressed in the E.coli strain K12 acuI deletion.
   
  
 0.763
ampR
Transcriptional regulator, LysR family; IMG reference gene:2512957280; PFAM: LysR substrate binding domain; Bacterial regulatory helix-turn-helix protein, lysR family; Belongs to the LysR transcriptional regulatory family.
    
 
 0.760
dddL
Dimethylsulfoniopropionate lyase DddL; May cleave dimethlysulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethlysulfonioproprionate lyase in vivo (Probable); Belongs to the non-heme iron-dependent dioxygenase family.
   
  
 0.684
RSP_1486
Transcriptional regulator, TetR family; IMG reference gene:2512953378; PFAM: Bacterial regulatory proteins, tetR family.
  
  
 0.650
kdpD
Osmosensitive K+ channel histidine kinase; IMG reference gene:2512956312; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Universal stress protein family; His Kinase A (phosphoacceptor) domain; Osmosensitive K+ channel His kinase sensor domain.
      
 0.622
bioA
IMG reference gene:2512956766; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.612
kdpE
Two component transcriptional regulator, winged helix family; IMG reference gene:2512956313; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal.
      
 0.610
lexA
LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the direct repeat sequence 5'-GTT-N(7)-GTTC-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
   
  
 0.599
RSP_2802
Multidrug/cation efflux pump, membrane fusion protein subunit; IMG reference gene:2512954812; TIGRFAM: RND family efflux transporter, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 0.566
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.