node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobB | cobE | RSP_3185 | RSP_2822 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | 0.950 |
cobB | cobF | RSP_3185 | RSP_2819 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | 0.931 |
cobB | cobH | RSP_3185 | RSP_6217 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | IMG reference gene:2512954782; PFAM: Precorrin-8X methylmutase. | 0.999 |
cobB | cobI | RSP_3185 | RSP_2826 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-2 C20-methyltransferase; IMG reference gene:2512954783; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.977 |
cobB | cobJ | RSP_3185 | RSP_2824 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-3 methyltransferase; IMG reference gene:2512954784; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.971 |
cobB | cobK | RSP_3185 | RSP_2825 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | precorrin-6A reductase; IMG reference gene:2512954785; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | 0.956 |
cobB | cobL | RSP_3185 | RSP_2823 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Putative Precorrin-6y C5,15-methyltransferase; IMG reference gene:2512954786; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | 0.975 |
cobB | cobM | RSP_3185 | RSP_2821 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Precorrin-4 C11-methyltransferase; IMG reference gene:2512954788; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.978 |
cobB | cobQ | RSP_3185 | RSP_0796 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.988 |
cobB | cobV | RSP_3185 | RSP_2427 | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.869 |
cobE | cobB | RSP_2822 | RSP_3185 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.950 |
cobE | cobF | RSP_2822 | RSP_2819 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | precorrin-6A synthase (deacetylating); Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. | 0.998 |
cobE | cobH | RSP_2822 | RSP_6217 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | IMG reference gene:2512954782; PFAM: Precorrin-8X methylmutase. | 0.970 |
cobE | cobI | RSP_2822 | RSP_2826 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Precorrin-2 C20-methyltransferase; IMG reference gene:2512954783; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.993 |
cobE | cobJ | RSP_2822 | RSP_2824 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Precorrin-3 methyltransferase; IMG reference gene:2512954784; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase. | 0.995 |
cobE | cobK | RSP_2822 | RSP_2825 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | precorrin-6A reductase; IMG reference gene:2512954785; PFAM: Precorrin-6x reductase CbiJ/CobK; TIGRFAM: precorrin-6x reductase. | 0.996 |
cobE | cobL | RSP_2822 | RSP_2823 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Putative Precorrin-6y C5,15-methyltransferase; IMG reference gene:2512954786; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit. | 0.998 |
cobE | cobM | RSP_2822 | RSP_2821 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Precorrin-4 C11-methyltransferase; IMG reference gene:2512954788; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.999 |
cobE | cobQ | RSP_2822 | RSP_0796 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.671 |
cobE | cobV | RSP_2822 | RSP_2427 | Putative precorrin methylase; IMG reference gene:2512954787; PFAM: Cobalamin synthesis G C-terminus. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.682 |