STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemBIMG reference gene:2512954756; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (334 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 
 0.999
RSP_1569
Glutamate-1-semialdehyde 2,1-aminomutase; IMG reference gene:2512953464; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.994
hemA
5-aminolevulinate synthase; IMG reference gene:2512954950; PFAM: Aminotransferase class I and II; TIGRFAM: 5-aminolevulinic acid synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.976
RSP_6208
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.929
hemT
5-aminolevulinate synthase; IMG reference gene:2512956527; PFAM: Aminotransferase class I and II; TIGRFAM: 5-aminolevulinic acid synthase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
    
 0.922
RSP_1944
uroporphyrinogen-III C-methyltransferase; IMG reference gene:2512953857; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.897
cobA
uroporphyrinogen-III C-methyltransferase; IMG reference gene:2512954789; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
  
 0.893
gltX/glnS
Glutamyl-/ glutaminyl-tRNA synthetase; IMG reference gene:2512954571; PFAM: tRNA synthetases class I (E and Q), catalytic domain; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
  
 0.865
hemF
Coproporphyrinogen oxidase; IMG reference gene:2512955703; PFAM: Coproporphyrinogen III oxidase.
 
  
 0.843
HemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.833
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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