node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSP_0599 | coaD | RSP_0599 | RSP_2960 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.945 |
RSP_0599 | coaE | RSP_0599 | RSP_1235 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.543 |
RSP_0599 | coaX | RSP_0599 | RSP_2533 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.946 |
RSP_0599 | gmk | RSP_0599 | RSP_2919 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.611 |
RSP_0599 | metK | RSP_0599 | RSP_3595 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.820 |
RSP_0599 | ribF | RSP_0599 | RSP_2304 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | FMN adenylyltransferase; IMG reference gene:2512954238; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.680 |
RSP_0901 | coaD | RSP_0901 | RSP_2960 | N-6 Adenine-specific DNA methylase; IMG reference gene:2512955933; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.974 |
RSP_0901 | gmk | RSP_0901 | RSP_2919 | N-6 Adenine-specific DNA methylase; IMG reference gene:2512955933; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.521 |
RSP_0901 | ribF | RSP_0901 | RSP_2304 | N-6 Adenine-specific DNA methylase; IMG reference gene:2512955933; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family. | FMN adenylyltransferase; IMG reference gene:2512954238; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.414 |
RSP_2920 | coaD | RSP_2920 | RSP_2960 | TIGR00255 family protein; IMG reference gene:2512954882; PFAM: YicC-like family, N-terminal region; Domain of unknown function (DUF1732); TIGRFAM: TIGR00255 family protein. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.760 |
RSP_2920 | gmk | RSP_2920 | RSP_2919 | TIGR00255 family protein; IMG reference gene:2512954882; PFAM: YicC-like family, N-terminal region; Domain of unknown function (DUF1732); TIGRFAM: TIGR00255 family protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.982 |
RSP_2961 | coaD | RSP_2961 | RSP_2960 | IMG reference gene:2512954927; PFAM: CBS domain. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.725 |
RSP_2961 | guaA | RSP_2961 | RSP_0005 | IMG reference gene:2512954927; PFAM: CBS domain. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.503 |
coaD | RSP_0599 | RSP_2960 | RSP_0599 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.945 |
coaD | RSP_0901 | RSP_2960 | RSP_0901 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | N-6 Adenine-specific DNA methylase; IMG reference gene:2512955933; PFAM: Conserved hypothetical protein 95; TIGRFAM: RNA methyltransferase, RsmD family. | 0.974 |
coaD | RSP_2920 | RSP_2960 | RSP_2920 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | TIGR00255 family protein; IMG reference gene:2512954882; PFAM: YicC-like family, N-terminal region; Domain of unknown function (DUF1732); TIGRFAM: TIGR00255 family protein. | 0.760 |
coaD | RSP_2961 | RSP_2960 | RSP_2961 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | IMG reference gene:2512954927; PFAM: CBS domain. | 0.725 |
coaD | coaE | RSP_2960 | RSP_1235 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.947 |
coaD | coaX | RSP_2960 | RSP_2533 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.950 |
coaD | gmk | RSP_2960 | RSP_2919 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.647 |