STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RSP_3389IMG reference gene:2512956900; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase. (357 aa)    
Predicted Functional Partners:
ilvH
IMG reference gene:2512954579; PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit.
  
 0.983
RSP_3388
IMG reference gene:2512956899; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase.
 
 
 
0.976
leuC
Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.973
RSP_2637
Acetolactate synthase, large subunit; IMG reference gene:2512954580; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.
 0.961
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 0.957
RSP_3155
IMG reference gene:2512956664; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
 
 0.942
ttdB
Putative Tartrate dehydratase beta subunit; IMG reference gene:2512956654; PFAM: Fumarase C-terminus; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region.
  
 
 0.919
ttdA
Fumarase alpha subunit; IMG reference gene:2512956655; PFAM: Fumarate hydratase (Fumerase); TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region.
  
 
 0.908
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.893
RSP_3386
TRAP-T family transporter, periplasmic binding protein; IMG reference gene:2512956897; PFAM: Tripartite tricarboxylate transporter family receptor.
 
     0.754
Your Current Organism:
Rhodobacter sphaeroides 241
NCBI taxonomy Id: 272943
Other names: R. sphaeroides 2.4.1, Rhodobacter sphaeroides 2.4.1, Rhodobacter sphaeroides ATCC 17023, Rhodobacter sphaeroides ATH 2.4.1, Rhodobacter sphaeroides str. 2.4.1, Rhodobacter sphaeroides strain 2.4.1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.