STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RP665FUMARATE HYDRATASE (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)    
Predicted Functional Partners:
RP128
SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT (sdhA).
 
 0.998
RP373
MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
  
 
 0.990
RP044
SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.989
RP376
MALATE DEHYDROGENASE (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.988
RP126
SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT (sdhC); Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.976
RP844
CITRATE SYNTHASE (gltA).
  
 0.947
RP127
SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR PROTEIN (sdhD); Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
 
 0.924
RP091
ASPARTATE AMINOTRANSFERASE A (aatA); Catalyzes the reversible conversion of aspartate and 2- oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
   
 0.834
RP432
SUCCINYL-COA LIGASE (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.815
RP355
NADH DEHYDROGENASE I CHAIN C (nuoC); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family.
   
 
 0.786
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
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