STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RP741Unknown; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (180 aa)    
Predicted Functional Partners:
RP535
SUPEROXIDE DISMUTASE (sodB); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
   
 
 0.938
RP600
Unknown.
   
   0.922
RP740
HEMOLYSIN C (tlyC).
  
  
 0.882
RP620
2-ACYLGLYCEROPHOSPHOETHANOLAMINE ACYLTRANSFERASE (aas).
   
 
 0.866
RP184
DNAJ PROTEIN (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
  
 
 0.843
RP634
50S RIBOSOMAL PROTEIN L17 (rplQ).
   
   0.843
RP650
30S RIBOSOMAL PROTEIN S17 (rpsQ); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
   
 
 0.841
RP118
GTP-BINDING PROTEIN ERA (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
  
  
 0.838
RP136
50S RIBOSOMAL PROTEIN L11 (rplK); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
   0.834
RP751
50S RIBOSOMAL PROTEIN L21 (rplU); This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
   0.829
Your Current Organism:
Rickettsia prowazekii
NCBI taxonomy Id: 272947
Other names: R. prowazekii str. Madrid E, Rickettsia prowazekii str. Madrid E, Rickettsia prowazekii strain Madrid E
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