node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RP044 | RP373 | gene:17555127 | gene:17555453 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | 0.765 |
RP044 | RP376 | gene:17555127 | gene:17555456 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | MALATE DEHYDROGENASE (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.872 |
RP044 | RP433 | gene:17555127 | gene:17555513 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | SUCCINYL-COA SYNTHETASE BETA CHAIN (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.990 |
RP044 | RP530 | gene:17555127 | gene:17555610 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT (pdhC); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.797 |
RP044 | RP560 | gene:17555127 | gene:17555640 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | PROBABLE 3-HYDROXYACYL-COA DEHYDROGENASE B0272.3 (fadB); In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.668 |
RP044 | RP665 | gene:17555127 | gene:17555742 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | FUMARATE HYDRATASE (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.989 |
RP044 | RP737 | gene:17555127 | gene:17555807 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | ACETYL-COA ACETYLTRANSFERASE (fadA); Belongs to the thiolase-like superfamily. Thiolase family. | 0.507 |
RP044 | RP799 | gene:17555127 | gene:17555868 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | ACONITATE HYDRATASE (acnA); Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. | 0.888 |
RP044 | RP803 | gene:17555127 | gene:17555872 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | ATP SYNTHASE ALPHA CHAIN (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. | 0.829 |
RP044 | RP844 | gene:17555127 | gene:17555913 | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | CITRATE SYNTHASE (gltA). | 0.947 |
RP373 | RP044 | gene:17555453 | gene:17555127 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.765 |
RP373 | RP376 | gene:17555453 | gene:17555456 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | MALATE DEHYDROGENASE (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.988 |
RP373 | RP433 | gene:17555453 | gene:17555513 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | SUCCINYL-COA SYNTHETASE BETA CHAIN (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.836 |
RP373 | RP530 | gene:17555453 | gene:17555610 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT (pdhC); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). | 0.834 |
RP373 | RP560 | gene:17555453 | gene:17555640 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | PROBABLE 3-HYDROXYACYL-COA DEHYDROGENASE B0272.3 (fadB); In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. | 0.878 |
RP373 | RP665 | gene:17555453 | gene:17555742 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | FUMARATE HYDRATASE (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.990 |
RP373 | RP737 | gene:17555453 | gene:17555807 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | ACETYL-COA ACETYLTRANSFERASE (fadA); Belongs to the thiolase-like superfamily. Thiolase family. | 0.761 |
RP373 | RP799 | gene:17555453 | gene:17555868 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | ACONITATE HYDRATASE (acnA); Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. | 0.678 |
RP373 | RP844 | gene:17555453 | gene:17555913 | MALIC ENZYME (tme); In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family. | CITRATE SYNTHASE (gltA). | 0.969 |
RP376 | RP044 | gene:17555456 | gene:17555127 | MALATE DEHYDROGENASE (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN (sdhB); Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.872 |