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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pthConserved hypothetical protein; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH2 family. (120 aa)    
Predicted Functional Partners:
truD
Conserved hypothetical protein; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.
 
     0.888
EF1B
Translation elongation factor EF-1, beta subunit (EF1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
  
    0.719
SSO5343
Conserved hypothetical protein; Similar to MJ0458.1, Ta0567, AF0573.
       0.716
SSO1046
Hypothetical ATP/GTP binding protein.
  
 
  0.690
rad2
DNA repair endo/exonuclease FEN-1 (RAD2) (rad2); Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base exci [...]
 
     0.638
psmA
Proteasome subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
   0.567
rpl4AE
LSU ribosomal protein L4AE (rpl4AE); One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
     0.549
SSO0176
AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes.
   
   0.536
eiF6
Translation initiation factor 6 (eiF 6) (eiF6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. Inhibits translation of both leadered and leaderless mRNAs, maybe by binding to the 50S ribosome subunit, preventing it from binding to the 30S subunit; Belongs to the eIF-6 family.
 
    0.523
SSO0939
Pre mRNA splicing protein; Regulation, RNA modification.
 
    0.510
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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