node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HemB | SSO0184 | SSO0181 | SSO0184 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.992 |
HemB | cbiA | SSO0181 | SSO0404 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.572 |
HemB | cbiL | SSO0181 | SSO2301 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Cobalamin biosynthesis precorrin-2 methyltransferase, putative (cbiL); Cofactor Biosynthesis; Belongs to the precorrin methyltransferase family. | 0.497 |
HemB | cbiT | SSO0181 | SSO2303 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Cobalamin biosynthesis precorrin-8W decarboxylase, putative (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.498 |
HemB | cbiX | SSO0181 | SSO0410 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily. | 0.537 |
HemB | cobS | SSO0181 | SSO3234 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Cobalamin synthase related protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.523 |
HemB | hemA | SSO0181 | SSO0180 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.978 |
HemB | hemC | SSO0181 | SSO0183 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
HemB | hemL | SSO0181 | SSO0182 | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | Glutamate-1-semialdehyde aminotransferase (hemL); Cofactor Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.999 |
SSO0184 | HemB | SSO0184 | SSO0181 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | 0.992 |
SSO0184 | cbiA | SSO0184 | SSO0404 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.569 |
SSO0184 | cbiL | SSO0184 | SSO2301 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin biosynthesis precorrin-2 methyltransferase, putative (cbiL); Cofactor Biosynthesis; Belongs to the precorrin methyltransferase family. | 0.448 |
SSO0184 | cbiT | SSO0184 | SSO2303 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin biosynthesis precorrin-8W decarboxylase, putative (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.561 |
SSO0184 | cbiX | SSO0184 | SSO0410 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily. | 0.700 |
SSO0184 | cobS | SSO0184 | SSO3234 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Cobalamin synthase related protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.545 |
SSO0184 | hemA | SSO0184 | SSO0180 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.961 |
SSO0184 | hemC | SSO0184 | SSO0183 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.999 |
SSO0184 | hemL | SSO0184 | SSO0182 | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde aminotransferase (hemL); Cofactor Biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.946 |
cbiA | HemB | SSO0404 | SSO0181 | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Delta-aminolevulinic acid dehydratase; Cofactor Biosynthesis; Belongs to the ALAD family. | 0.572 |
cbiA | SSO0184 | SSO0404 | SSO0184 | Cobyrinic acid A,C diamisynthase (CBIA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Uroporphyrinogen III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.569 |