STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
purAAdenylosuccinate synthase (IMP--aspartate ligase) (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (335 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase (adenylosuccinase)(ASL) (purB); Purines; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 0.999
pyrB
Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines.
  
 
 0.967
argG
Argininosuccinate synthetase (argG); Amino Acid Biosynthesis, Glutamate; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.956
EF-2
Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
 
 
 0.939
purL
Phosphoribosylformylglycinamidine synthase II (FGAM synthase II) (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...]
  
  
 0.937
purD
Phosphoribosylamine--glycine ligase (GAR synthetase) (GARS) (purD); Purines; Belongs to the GARS family.
  
 
 0.937
ansA-like
Asparinase, putative (ansA-like); Amino Acid Biosynthesis, Aspartate.
    
  0.936
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine.
  
  
 0.935
aspB-2
Aspartate aminotransferase (aspB-2); Amino Acid Biosynthesis, Aspartate.
  
 0.934
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase) (purC); Purines; Belongs to the SAICAR synthetase family.
  
 
 0.927
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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