node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSO2415 | ribA | SSO2415 | SSO0402 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.468 |
SSO2415 | ribD | SSO2415 | SSO2097 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.684 |
SSO2415 | ribH | SSO2415 | SSO0400 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.813 |
cbiX | ribH | SSO0410 | SSO0400 | Conserved hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Belongs to the CbiX family. CbiXS subfamily. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.912 |
gch3 | ribA | SSO0399 | SSO0402 | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.852 |
gch3 | ribC | SSO0399 | SSO0401 | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. | Riboflavin synthase (ribC); Cofactor Biosynthesis, Riboflavin. | 0.852 |
gch3 | ribH | SSO0399 | SSO0400 | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.852 |
gch3 | trzA-like | SSO0399 | SSO0398 | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. | Close hit to N ethylammeline chlorohydrolase related protein; Cellular Processes. | 0.852 |
pyrB | pyrD | SSO0614 | SSO0610 | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.999 |
pyrB | ribA | SSO0614 | SSO0402 | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.517 |
pyrB | ribH | SSO0614 | SSO0400 | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.861 |
pyrD | pyrB | SSO0610 | SSO0614 | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. | 0.999 |
pyrD | ribH | SSO0610 | SSO0400 | Dihydroorotate dehydrogenase (dihydroorotate oxidase) (DHOdehase) (pyrD); Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.938 |
ribA | SSO2415 | SSO0402 | SSO2415 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | 0.468 |
ribA | gch3 | SSO0402 | SSO0399 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. | 0.852 |
ribA | pyrB | SSO0402 | SSO0614 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | Aspartate carbamoyltransferase catalytic chain (ATCase) (pyrB); Pyrimidines. | 0.517 |
ribA | ribC | SSO0402 | SSO0401 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | Riboflavin synthase (ribC); Cofactor Biosynthesis, Riboflavin. | 0.972 |
ribA | ribD | SSO0402 | SSO2097 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.973 |
ribA | ribH | SSO0402 | SSO0400 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
ribA | trzA-like | SSO0402 | SSO0398 | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | Close hit to N ethylammeline chlorohydrolase related protein; Cellular Processes. | 0.854 |