node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSO0421 | SSO0422 | SSO0421 | SSO0422 | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. | Conserved hypothetical protein; Similarity with APE1343. Possibly a nitrilase. | 0.602 |
SSO0421 | apgM | SSO0421 | SSO0417 | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.849 |
SSO0421 | topR-1 | SSO0421 | SSO0420 | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.605 |
SSO0422 | SSO0421 | SSO0422 | SSO0421 | Conserved hypothetical protein; Similarity with APE1343. Possibly a nitrilase. | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. | 0.602 |
SSO0422 | apgM | SSO0422 | SSO0417 | Conserved hypothetical protein; Similarity with APE1343. Possibly a nitrilase. | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | 0.602 |
SSO0422 | topR-1 | SSO0422 | SSO0420 | Conserved hypothetical protein; Similarity with APE1343. Possibly a nitrilase. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.852 |
SSO1152 | topR-1 | SSO1152 | SSO0420 | Conserved hypothetical protein. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.612 |
apgM | SSO0421 | SSO0417 | SSO0421 | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. | 0.849 |
apgM | SSO0422 | SSO0417 | SSO0422 | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Conserved hypothetical protein; Similarity with APE1343. Possibly a nitrilase. | 0.602 |
apgM | topR-1 | SSO0417 | SSO0420 | Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.603 |
creN7 | ssh7A | SSO6901 | SSO10610 | Conserved hypothetical protein; A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly. Belongs to the Cren7 family. | 7 KD DNA-binding protein (SSO7D) (SSH7A) (ssh7A; Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature (By similarity). Stimulates the Holliday junction cleavage activity of Hjc ; Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family. | 0.870 |
creN7 | topR-1 | SSO6901 | SSO0420 | Conserved hypothetical protein; A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly. Belongs to the Cren7 family. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.555 |
nurA | topR-1 | SSO2248 | SSO0420 | Conserved hypothetical protein; Involved in DNA double-strand break (DSB) repair. Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Processes linear dsDNA probes with 3' or 5' single-stranded overhangs or blunt ends. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.547 |
ogG | topR-1 | SSO0904 | SSO0420 | 8-oxoguanine DNA glycosylase (ogG); Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites); Belongs to the type-2 OGG1 family. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.686 |
ssh7A | creN7 | SSO10610 | SSO6901 | 7 KD DNA-binding protein (SSO7D) (SSH7A) (ssh7A; Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature (By similarity). Stimulates the Holliday junction cleavage activity of Hjc ; Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family. | Conserved hypothetical protein; A highly abundant probable chromatin protein, it binds double-strand DNA without sequence specificity; there is approximately 1 Cren7 molecule for 12 bp of DNA. Constrains negative DNA supercoils, increases DNA stability against thermal denaturation. Binding does not require protein methylation. Binds single-strand DNA weakly. Belongs to the Cren7 family. | 0.870 |
ssh7A | topR-1 | SSO10610 | SSO0420 | 7 KD DNA-binding protein (SSO7D) (SSH7A) (ssh7A; Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature (By similarity). Stimulates the Holliday junction cleavage activity of Hjc ; Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.611 |
sucC | topR-1 | SSO2483 | SSO0420 | Succinyl-CoA synthetase, beta subunit (sucC); Energy Metabolism. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.652 |
taw3 | topR-1 | SSO0622 | SSO0420 | Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | 0.560 |
topR-1 | SSO0421 | SSO0420 | SSO0421 | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | AAA family ATPase; Similar to confirmed SAV protein (S. acidocaldarius); Cellular Processes. | 0.605 |
topR-1 | SSO0422 | SSO0420 | SSO0422 | Reverse gyrase (topR-1); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA- binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase. In the C-terminal section; belongs [...] | Conserved hypothetical protein; Similarity with APE1343. Possibly a nitrilase. | 0.852 |