node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MvaD | SSO0535 | SSO2989 | SSO0535 | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.956 |
MvaD | crtB | SSO2989 | SSO2905 | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. | Phytoene synthetase (crtB); Cofactor Biosynthesis, Caretenoid Biosynthesis. | 0.635 |
MvaD | gdS-1 | SSO2989 | SSO0061 | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. | Geranylgeranyl pyrophosphate synthetase (gdS-1); Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids; Belongs to the FPP/GGPP synthase family. | 0.958 |
MvaD | hmgA | SSO2989 | SSO0531 | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. | 3 hydroxy 3 methylglutaryl coenzyme a reductase; Converts HMG-CoA to mevalonate; Belongs to the HMG-CoA reductase family. | 0.877 |
MvaD | mvk | SSO2989 | SSO0383 | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.989 |
SSO0532 | SSO0535 | SSO0532 | SSO0535 | Conserved hypothetical protein; Unknown protein in pyrococcus furiosus aca operon. | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.997 |
SSO0532 | acaB-1 | SSO0532 | SSO0534 | Conserved hypothetical protein; Unknown protein in pyrococcus furiosus aca operon. | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. | 0.992 |
SSO0532 | glyA | SSO0532 | SSO0530 | Conserved hypothetical protein; Unknown protein in pyrococcus furiosus aca operon. | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine. | 0.717 |
SSO0532 | hmgA | SSO0532 | SSO0531 | Conserved hypothetical protein; Unknown protein in pyrococcus furiosus aca operon. | 3 hydroxy 3 methylglutaryl coenzyme a reductase; Converts HMG-CoA to mevalonate; Belongs to the HMG-CoA reductase family. | 0.852 |
SSO0535 | MvaD | SSO0535 | SSO2989 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Diphosphomevalonate decarboxylase, putative; Catalyzes the decarboxylation of mevalonate 5-diphosphate (MVAPP) to isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids. Belongs to the diphosphomevalonate decarboxylase family. | 0.956 |
SSO0535 | SSO0532 | SSO0535 | SSO0532 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Conserved hypothetical protein; Unknown protein in pyrococcus furiosus aca operon. | 0.997 |
SSO0535 | acaB-1 | SSO0535 | SSO0534 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. | 0.999 |
SSO0535 | crtB | SSO0535 | SSO2905 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Phytoene synthetase (crtB); Cofactor Biosynthesis, Caretenoid Biosynthesis. | 0.893 |
SSO0535 | gdS-1 | SSO0535 | SSO0061 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Geranylgeranyl pyrophosphate synthetase (gdS-1); Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids; Belongs to the FPP/GGPP synthase family. | 0.597 |
SSO0535 | glyA | SSO0535 | SSO0530 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine. | 0.746 |
SSO0535 | hmgA | SSO0535 | SSO0531 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | 3 hydroxy 3 methylglutaryl coenzyme a reductase; Converts HMG-CoA to mevalonate; Belongs to the HMG-CoA reductase family. | 0.999 |
SSO0535 | mvk | SSO0535 | SSO0383 | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. | 0.903 |
acaB-1 | SSO0532 | SSO0534 | SSO0532 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. | Conserved hypothetical protein; Unknown protein in pyrococcus furiosus aca operon. | 0.992 |
acaB-1 | SSO0535 | SSO0534 | SSO0535 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. | Acyl carrier protein synthase; Lipid metabolism; Belongs to the thiolase-like superfamily. UPF0219 family. | 0.999 |
acaB-1 | glyA | SSO0534 | SSO0530 | Acetyl-CoA c-acetyltransferase (acetoacetyl-CoA thiolase) (acaB-1); Lipid metabolism. | Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta-phenylserine. | 0.774 |