node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SSO2415 | folE | SSO2415 | SSO0364 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | GTP cyclohydrolase I (folE); Purines. | 0.996 |
SSO2415 | ribA | SSO2415 | SSO0402 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.468 |
SSO2415 | ribD | SSO2415 | SSO2097 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.684 |
SSO2415 | ribH | SSO2415 | SSO0400 | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.813 |
SSO2832 | ribD | SSO2832 | SSO2097 | Conserved hypothetical protein. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.560 |
dfp | ribA | SSO0210 | SSO0402 | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.602 |
dfp | ribD | SSO0210 | SSO2097 | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.535 |
dfp | uppS | SSO0210 | SSO0163 | DNA/pantothenate metabolism flavoprotein (dfp); Cofactor Biosynthesis, Panthenate. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. | 0.616 |
folE | SSO2415 | SSO0364 | SSO2415 | GTP cyclohydrolase I (folE); Purines. | Dihydropteroate synthase, putative; Cofactor Biosynthesis. | 0.996 |
folE | ribA | SSO0364 | SSO0402 | GTP cyclohydrolase I (folE); Purines. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.551 |
folE | ribD | SSO0364 | SSO2097 | GTP cyclohydrolase I (folE); Purines. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.582 |
folE | ribH | SSO0364 | SSO0400 | GTP cyclohydrolase I (folE); Purines. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.550 |
hisG | pyrE | SSO0593 | SSO0615 | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.423 |
hisG | ribA | SSO0593 | SSO0402 | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.437 |
hisG | ribD | SSO0593 | SSO2097 | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.602 |
hisG | ribH | SSO0593 | SSO0400 | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.487 |
pyrE | hisG | SSO0615 | SSO0593 | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | ATP phosphoribosyl transferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.423 |
pyrE | ribA | SSO0615 | SSO0402 | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | GTP Cyclohydrolase II (3,4-Dihydroxy-2-Butanone 4- Phosphate Synthase (DHBP synthase) (ribA); Cofactor Biosynthesis, Riboflavin. | 0.419 |
pyrE | ribD | SSO0615 | SSO2097 | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 5-amino-6-(5-phosphoribosylamino)uracil reductase (ribD); Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6- ribitylamino-4(3H)-pyrimidinone 5'-phosphate. | 0.570 |
pyrE | ribH | SSO0615 | SSO0400 | Orotate phosphoribosyltransferase (OPRT) (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | Riboflavin synthase beta chain (6,7 dimethyl 8-ribityllumazine synthase) (DMRKL synthase) (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.511 |