| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Dph2 | SSO2158 | SSO0293 | SSO2158 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein; Putative methyltransferase. | 0.611 |
| Dph2 | csl4 | SSO0293 | SSO0292 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.945 |
| Dph2 | rpl10E | SSO0293 | SSO0294 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | LSU ribosomal protein L10E (rpl10E); Translation, Ribosomal Proteins; Belongs to the universal ribosomal protein uL16 family. | 0.980 |
| Dph2 | rpoL | SSO0293 | SSO5577 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase, subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.961 |
| Dph2 | rpoM-1 | SSO0293 | SSO0291 | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA-directed RNA polymerase, subunit M (rpoM-1); Possible in-frame shift with SSO5576. Similar to carboxy-end of RPOM_SULAC, but most other thermophilic genes are the same size; Transcription, RNA polymerase and transcription factors; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.926 |
| SSO2158 | Dph2 | SSO2158 | SSO0293 | Hypothetical protein; Putative methyltransferase. | Conserved hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.611 |
| SSO2158 | SSO2159 | SSO2158 | SSO2159 | Hypothetical protein; Putative methyltransferase. | 2-haloalkanoic acid dehalogenase; Uncategorized. | 0.758 |
| SSO2158 | SSO2160 | SSO2158 | SSO2160 | Hypothetical protein; Putative methyltransferase. | Conserved hypothetical protein; Similarity with PAB3329, AF2182. | 0.711 |
| SSO2158 | SSO2213 | SSO2158 | SSO2213 | Hypothetical protein; Putative methyltransferase. | Conserved hypothetical protein; Similar to PH0034, PAB2326, AF0276, MTH1426, APE2029, MJ1598, Ta0078; Belongs to the UPF0284 family. | 0.606 |
| SSO2158 | SSO2391 | SSO2158 | SSO2391 | Hypothetical protein; Putative methyltransferase. | Conserved hypothetical protein. | 0.592 |
| SSO2158 | csl4 | SSO2158 | SSO0292 | Hypothetical protein; Putative methyltransferase. | Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. | 0.611 |
| SSO2158 | rfbD-3 | SSO2158 | SSO2161 | Hypothetical protein; Putative methyltransferase. | dTDP-4-dehydrorhamnose reductase (rfbD-3); Cell Envelope, Surface polysaccharides and lipopolysaccharides. | 0.478 |
| SSO2158 | rpl10E | SSO2158 | SSO0294 | Hypothetical protein; Putative methyltransferase. | LSU ribosomal protein L10E (rpl10E); Translation, Ribosomal Proteins; Belongs to the universal ribosomal protein uL16 family. | 0.619 |
| SSO2158 | rpoL | SSO2158 | SSO5577 | Hypothetical protein; Putative methyltransferase. | DNA-directed RNA polymerase, subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.644 |
| SSO2158 | rpoM-1 | SSO2158 | SSO0291 | Hypothetical protein; Putative methyltransferase. | DNA-directed RNA polymerase, subunit M (rpoM-1); Possible in-frame shift with SSO5576. Similar to carboxy-end of RPOM_SULAC, but most other thermophilic genes are the same size; Transcription, RNA polymerase and transcription factors; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. | 0.521 |
| SSO2159 | SSO2158 | SSO2159 | SSO2158 | 2-haloalkanoic acid dehalogenase; Uncategorized. | Hypothetical protein; Putative methyltransferase. | 0.758 |
| SSO2159 | SSO2160 | SSO2159 | SSO2160 | 2-haloalkanoic acid dehalogenase; Uncategorized. | Conserved hypothetical protein; Similarity with PAB3329, AF2182. | 0.946 |
| SSO2159 | SSO2213 | SSO2159 | SSO2213 | 2-haloalkanoic acid dehalogenase; Uncategorized. | Conserved hypothetical protein; Similar to PH0034, PAB2326, AF0276, MTH1426, APE2029, MJ1598, Ta0078; Belongs to the UPF0284 family. | 0.784 |
| SSO2159 | rfbD-3 | SSO2159 | SSO2161 | 2-haloalkanoic acid dehalogenase; Uncategorized. | dTDP-4-dehydrorhamnose reductase (rfbD-3); Cell Envelope, Surface polysaccharides and lipopolysaccharides. | 0.775 |
| SSO2160 | SSO2158 | SSO2160 | SSO2158 | Conserved hypothetical protein; Similarity with PAB3329, AF2182. | Hypothetical protein; Putative methyltransferase. | 0.711 |