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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadENH(3+) dependent NAD(+) synthetase (nadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (304 aa)    
Predicted Functional Partners:
SSO2174
Amidohydrolase, putative; Related to NH(3)-dependent NAD synthetase; Uncategorized.
   
 0.987
SSO0255
Nicotinamide mononucleotide adenylyltransferase, putative; Amino-end extention is missing compared to other homologues; Cofactor Biosynthesis, Pyridine nucleotides.
 
  
 0.970
nadK
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.968
SSO0354
Nicotinic acid phosphoribosyltransferase, putative; Cofactor Biosynthesis, Pyridine nucleotides.
 
  
 0.858
SSO2171
Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
       0.816
nadA
Quinolinate synthetase (nadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
  
  
 0.711
NadC
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
     
 0.697
adkA-like
Adenylate kinase related protein (adkA-like); Purines; Belongs to the UPF0200 family.
 
   
 0.693
bioR
Biotin--(acetyl-CoA carboxylase) synthetase (bioR); Cofactor Biosynthesis, Biotin.
 
  
 0.688
nadB
Aspartate oxidase (nadB); Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.661
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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