Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
asd-2Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (asd-2); Amino Acid Biosynthesis, Aspartate. (356 aa)    
Predicted Functional Partners:
akH
Aspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family.
 
  
 0.959
sucD
Succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.921
sucC
Succinyl-CoA synthetase, beta subunit (sucC); Energy Metabolism.
  
 
 0.920
accC
Biotin carboxylase a subunit of propionyl-CoA carboxylase (accC); Lipid metabolism.
    
 0.910
mcmA1
Methylmalonyl-CoA mutase, alpha-subunit, chain A (mcmA1); Highly conserved with Pyrococcus and Archaeoglobus; Cellular Processes, Detoxification.
    
 0.908
hdb-1
3-hydroxyacyl-CoA dehydrogenase (hdb-1); Lipid metabolism.
    
 0.907
ppcB
Propionyl-CoA carboxylase beta subunit (ppcB); Lipid metabolism.
    
 0.907
SSO2464
Biotin carboxyl carrier protein of propionyl-CoA carboxylase beta subunit; Lipid metabolism.
    
 0.906
SSO2815
2-oxoacid--ferredoxin oxidoreductase, alpha chain; Energy Metabolism.
  
 
  0.904
mcmA2
Methylmalonyl-CoA mutase, alpha-subunit, chain B (mcmA2); Cellular Processes, Detoxification.
    
  0.903
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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