Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppcAConserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (511 aa)    
Predicted Functional Partners:
sqdB-2
L-lactate dehydrogenase (sqdB); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily.
     
 0.951
pyK
Pyruvate kinase (pyK); Energy Metabolism, Glycolysis; Belongs to the pyruvate kinase family.
     
 0.949
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.948
ppsA-1
Phosphoenolpyruvate synthase (ppsA-1); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.920
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
gltA
Citrate synthase; Energy Metabolism; Belongs to the citrate synthase family.
     
 0.895
apgM
Phosphonopyruvate decarboxylase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
  
 0.848
SSO2236
Phosphoglycerate mutase, putative; Energy Metabolism, Sugar metabolism.
     
 0.815
SSO2257
Conserved hypothetical protein; Similar to PH0727.
       0.813
pgk
Phosphoglycerate kinase; Energy Metabolism, Gluconeogenesis.
     
  0.800
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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