STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (311 aa)    
Predicted Functional Partners:
thrA/hom
Homoserine dehydrogenase (thrA/hom); Amino Acid Biosynthesis, Aspartate.
 
 0.999
thrC-2
Threonine synthase (thrC-2); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
 
 0.989
metB
O-succinylhomoserine (thiol)-lyase (cystathionine gamma-synthase) (metB); Amino Acid Biosynthesis.
  
 
 0.985
akH
Aspartokinase (akH); Amino Acid Biosynthesis, Aspartate; Belongs to the aspartokinase family.
 
 
 0.964
thrC-1
Threonine synthase (thrC-1); Amino Acid Biosynthesis, Aromatic amino acids.
  
 
 0.945
metE-1
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-1); Amino Acid Biosynthesis.
  
 
 0.855
metE-2
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE-2); Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity).
  
 
 0.855
ilvD
Dihydroxy-acid dehydratase (ilvD); Amino Acid Biosynthesis; Belongs to the IlvD/Edd family.
 
  
 0.844
ahcY
S-adenosyl-L-homocysteine hydrolase (ahcY); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
  0.802
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
  
 0.748
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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