node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argS | guaAA | STK_12580 | STK_05780 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | 0.770 |
argS | guaAB | STK_12580 | STK_23450 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | 0.913 |
argS | map | STK_12580 | STK_14190 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.509 |
argS | ntpA | STK_12580 | STK_03650 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.490 |
argS | purA | STK_12580 | STK_02910 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.465 |
argS | purB | STK_12580 | STK_02880 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.676 |
argS | purL | STK_12580 | STK_14950 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.619 |
argS | pyrH | STK_12580 | STK_13000 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.482 |
argS | rpl11p | STK_12580 | STK_13680 | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.822 |
guaAA | argS | STK_05780 | STK_12580 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.770 |
guaAA | guaAB | STK_05780 | STK_23450 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | 0.998 |
guaAA | map | STK_05780 | STK_14190 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. | 0.816 |
guaAA | ntpA | STK_05780 | STK_03650 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Nucleoside-triphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.947 |
guaAA | purA | STK_05780 | STK_02910 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.818 |
guaAA | purB | STK_05780 | STK_02880 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.722 |
guaAA | purD | STK_05780 | STK_14980 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylamine--glycine ligase; Protein synonym:glycinamide ribonucleotide synthetase. | 0.710 |
guaAA | purL | STK_05780 | STK_14950 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.670 |
guaAA | pyrH | STK_05780 | STK_13000 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.679 |
guaAA | rpl11p | STK_05780 | STK_13680 | GMP synthase [glutamine-hydrolyzing] subunit A; Catalyzes the synthesis of GMP from XMP. | 50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.792 |
guaAB | argS | STK_23450 | STK_12580 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.913 |