STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (809 aa)    
Predicted Functional Partners:
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
 
 
0.975
pheS
phenylalanyl-tRNA synthetase alpha chain; Protein synonym:phenylalanine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
 
  
 0.958
thrS1
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein.
 
  
 0.954
hisS
histidyl-tRNA synthetase; Protein synonym:histidine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
 
 0.943
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
 
 
 0.931
argS
arginyl-tRNA synthetase; Protein synonym:arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
  
 0.930
cysS
cysteinyl-tRNA synthetase; N-term changed (-9); protein synonym:cysteine--tRNA ligase.
 
  
 0.930
pheT
phenylalanyl-tRNA synthetase beta chain; Protein synonym:phenylalanine--tRNA ligase.
 
  
 0.920
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
 
  
 0.916
leuS
leucyl-tRNA synthetase; Protein synonym:leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
0.901
Your Current Organism:
Sulfurisphaera tokodaii
NCBI taxonomy Id: 273063
Other names: S. tokodaii str. 7, Sulfolobus sp. (strain 7), Sulfolobus sp. 7, Sulfolobus tokodaii str. 7, Sulfurisphaera tokodaii str. 7, Sulfurisphaera tokodaii strain 7
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.