STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RecFRecombinational DNA repair ATPase; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (364 aa)    
Predicted Functional Partners:
DnaN
DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 0.992
GyrB
DNA gyrase (topoisomerase II) B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-depen [...]
  
 0.958
DnaA
ATPase involved in DNA replication initiation; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
  
 0.948
TTE0003
Conserved hypothetical protein; Best Blastp hit = gi|140603|sp|P05650|YAAA_BACSU HYPOTHETICAL 7.9 KD PROTEIN IN DNAN-RECF INTERGENIC REGION gi|80349|pir||C22930 conserved hypothetical protein yaaA - Bacillus subtilis gi|40016|emb|CAA26219.1| (X02369) ORF 71 (aa 1-71) [Bacillus subtilis] gi|467393|dbj|BAA05239.1| (D26185) unknown [Bacillus subtilis] gi|2632270|emb|CAB11779.1| (Z99104) similar to hypothetical proteins [Bacillus subtilis], score 65.5, E-value 9.00E-11.
  
  
 0.928
RecR
Recombinational DNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
 
  
 0.920
TTE0005
Conserved hypothetical protein; Best Blastp hit = gi|11356527|pir||T46554 hypothetical protein X [imported] - Clostridium acetobutylicum gi|1790874|gb|AAB41129.1| (U35453) OrfX [Clostridium acetobutylicum], score 94, E-value 3.00E-19.
  
    0.895
RecO
Recombinational DNA repair protein; Involved in DNA repair and RecF pathway recombination.
    
 
 0.849
RnpA
RNase P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
  
  
 0.838
GyrA
DNA gyrase (topoisomerase II) A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-depen [...]
 
  
 0.836
TTE0006
Alpha-glucosidases, family 31 of glycosyl hydrolases; Best Blastp hit = gi|4586418|dbj|BAA76396.1| (AB012238) alpha-glucosidase [Bacillus thermoamyloliquefaciens], score 660, E-value 0; Belongs to the glycosyl hydrolase 31 family.
       0.773
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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