STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
CobSCobalamin-5-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (248 aa)    
Predicted Functional Partners:
CobU
Best Blastp hit = gi|7471254|pir||G75594 cobinamide kinase/cobinamide phosphate guanylyltransferase - Deinococcus radiodurans (strain R1) gi|6460576|gb|AAF12282.1|AE001862_108 (AE001862) cobinamide kinase/cobinamide phosphate guanylyltransferase [Deinococcus radiodurans], score 147, E-value 1.00E-34.
 
 
 0.998
CbiB
Cobalamin biosynthesis protein CobD/CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
 0.988
CobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.985
CobB
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
 
  
 0.977
BtuR
ATP:corrinoid adenosyltransferase; Best Blastp hit = gi|7462089|pir||B72252 cob(I)alamin adenosyltransferase - Thermotoga maritima (strain MSB8) gi|4982030|gb|AAD36533.1|AE001797_13 (AE001797) cob(I)alamin adenosyltransferase [Thermotoga maritima], score 177, E-value 6.00E-44.
 
 
 0.963
HisC
Histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
 
   
 0.953
BtuR2
ATP:corrinoid adenosyltransferase; Best Blastp hit = gi|7462089|pir||B72252 cob(I)alamin adenosyltransferase - Thermotoga maritima (strain MSB8) gi|4982030|gb|AAD36533.1|AE001797_13 (AE001797) cob(I)alamin adenosyltransferase [Thermotoga maritima], score 171, E-value 6.00E-42.
 
 
 0.942
TTE0379
Conserved hypothetical protein; Best Blastp hit = gi|10173468|dbj|BAB04572.1| (AP001510) BH0853; unknown [Bacillus halodurans], score 105, E-value 4.00E-22.
 
    0.904
TTE0378
Hypothetical protein.
 
     0.879
BtuC
ABC-type cobalamin/Fe3+-siderophores transport systems, permease components; Best Blastp hit = gi|10957443|ref|NP_051558.1| 'hemin ABC transporter, permease protein, putative [Deinococcus radiodurans]' gi|7473510|pir||G75619 'probable hemin ABC transporter, permease protein - Deinococcus radiodurans (strain R1)' gi|6460872|gb|AAF12576.1|AE001826_45 '(AE001826) hemin ABC transporter, permease protein, putative [Deinococcus radiodurans]', score 219, E-value 3.00E-56; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
  
  
 0.853
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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