Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GlyA | GuaB | TTE2130 | TTE0582 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.788 |
| GlyA | MIS1 | TTE2130 | TTE2391 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. | 0.982 |
| GlyA | PurA | TTE2130 | TTE2696 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.917 |
| GlyA | PurB | TTE2130 | TTE1367 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Best Blastp hit = gi|3983439|gb|AAC83935.1| (AF106656) adenylosuccinate lyase [Homo sapiens], score 469, E-value 1.00E-131; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.860 |
| GlyA | PurD | TTE2130 | TTE0593 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylamine-glycine ligase; Best Blastp hit = gi|10173248|dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase [Bacillus halodurans], score 408, E-value 1.00E-113. | 0.836 |
| GlyA | PurF | TTE2130 | TTE0812 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.837 |
| GlyA | PurH | TTE2130 | TTE0592 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174. | 0.995 |
| GlyA | PurM | TTE2130 | TTE0590 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylaminoimidazol (AIR) synthetase; Best Blastp hit = gi|11272453|pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB1252 [imported] - Neisseria meningitidis (group B strain MD58) gi|7226492|gb|AAF41632.1| (AE002473) phosphoribosylformylglycinamidine cyclo-ligase [Neisseria meningitidis MC58], score 375, E-value 1.00E-103. | 0.611 |
| GlyA | PurN | TTE2130 | TTE0591 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.974 |
| GuaB | GlyA | TTE0582 | TTE2130 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.788 |
| GuaB | MIS1 | TTE0582 | TTE2391 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. | 0.473 |
| GuaB | PurA | TTE0582 | TTE2696 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.995 |
| GuaB | PurB | TTE0582 | TTE1367 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate lyase; Best Blastp hit = gi|3983439|gb|AAC83935.1| (AF106656) adenylosuccinate lyase [Homo sapiens], score 469, E-value 1.00E-131; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.942 |
| GuaB | PurD | TTE0582 | TTE0593 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylamine-glycine ligase; Best Blastp hit = gi|10173248|dbj|BAB04353.1| (AP001509) phosphoribosylglycinamide synthetase [Bacillus halodurans], score 408, E-value 1.00E-113. | 0.864 |
| GuaB | PurE | TTE0582 | TTE0585 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.889 |
| GuaB | PurF | TTE0582 | TTE0812 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.899 |
| GuaB | PurH | TTE0582 | TTE0592 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Best Blastp hit = gi|10173247|dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans], score 611, E-value 1.00E-174. | 0.992 |
| GuaB | PurM | TTE0582 | TTE0590 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazol (AIR) synthetase; Best Blastp hit = gi|11272453|pir||E81104 phosphoribosylformylglycinamidine cyclo-ligase NMB1252 [imported] - Neisseria meningitidis (group B strain MD58) gi|7226492|gb|AAF41632.1| (AE002473) phosphoribosylformylglycinamidine cyclo-ligase [Neisseria meningitidis MC58], score 375, E-value 1.00E-103. | 0.925 |
| GuaB | PurN | TTE0582 | TTE0591 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.818 |
| MIS1 | GlyA | TTE2391 | TTE2130 | Formyltetrahydrofolate synthetase; Best Blastp hit = gi|120563|sp|P21164|FTHS_MOOTH FORMATE--TETRAHYDROFOLATE LIGASE (FORMYLTETRAHYDROFOLATE SYNTHETASE) (FHS) (FTHFS) gi|98640|pir||A35942 formate--tetrahydrofolate ligase (EC 6.3.4.3) - Clostridium thermaceticum gi|144816|gb|AAA23240.1| (J02911) formyltetrahydrofolate synthetase (FTHFS) (ttg start codon) (EC 6.3.4.3) [Moorella thermoacetica], score 744, E-value 0. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.982 |
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