STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IlvEBranched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (291 aa)    
Predicted Functional Partners:
LeuA
Isopropylmalate/homocitrate/citramalate synthases; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 0.996
IlvD
Dihydroxyacid dehydratase/phosphogluconate dehydratase; Best Blastp hit = gi|7436859|pir||F75045 dihydroxy-acid dehydratase (EC 4.2.1.9) (ilvd) PAB0895 - Pyrococcus abyssi (strain Orsay) gi|5458772|emb|CAB50259.1| (AJ248287) dihydroxy-acid dehydratase (EC 4.2.1.9) (ilvD) [Pyrococcus abyssi], score 690, E-value 0; Belongs to the IlvD/Edd family.
  
 0.995
MetC2
Cystathionine beta-lyases/cystathionine gamma-synthases; Best Blastp hit = gi|2500947|sp|P56069|METB_HELPY CYSTATHIONINE GAMMA-SYNTHASE (CGS) (O-SUCCINYLHOMOSERINE (THIOL)-LYASE) gi|7437084|pir||B64533 cystathionine gamma-synthase - Helicobacter pylori (strain 26695) gi|2313189|gb|AAD07176.1| (AE000532) cystathionine gamma-synthase (metB) [Helicobacter pylori 26695], score 330, E-value 3.00E-89.
   
 0.918
GdhA3
Glutamate dehydrogenase/leucine dehydrogenase; Best Blastp hit = gi|9087160|sp|Q59194|DHLE_BACCE LEUCINE DEHYDROGENASE (LEUDH) gi|1256412|gb|AAA96314.1| (U51099) leucine dehydrogenase LeuDH [Bacillus cereus], score 482, E-value 1.00E-135; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.916
GdhA4
Glutamate dehydrogenase/leucine dehydrogenase; Best Blastp hit = gi|80215|pir||A31950 leucine dehydrogenase (EC 1.4.1.9) - Bacillus stearothermophilus gi|143146|gb|AAA22570.1| (M22977) leucine dehydrogenase (EC 1.4.1.9) [Bacillus stearothermophilus], score 462, E-value 1.00E-129.
  
 
 0.916
LeuA2
Isopropylmalate/homocitrate/citramalate synthases; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.908
ThrA
Homoserine dehydrogenase; Best Blastp hit = gi|6648065|sp|P19582|DHOM_BACSU HOMOSERINE DEHYDROGENASE (HDH) gi|7427665|pir||DEECHS homoserine dehydrogenase (EC 1.1.1.3) - Bacillus subtilis gi|2635723|emb|CAB15216.1| (Z99120) homoserine dehydrogenase [Bacillus subtilis], score 234, E-value 2.00E-60.
  
 
 0.874
ThrA2
Homoserine dehydrogenase; Best Blastp hit = gi|7431120|pir||F69031 homoserine dehydrogenase (EC 1.1.1.3) - Methanobacterium thermoautotrophicum (strain Delta H) gi|2622343|gb|AAB85721.1| (AE000890) homoserine dehydrogenase [Methanothermobacter thermautotrophicus], score 283, E-value 2.00E-75.
  
 
 0.874
ThrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.853
IlvB
Acetolactate synthase; Best Blastp hit = gi|11499309|ref|NP_070548.1| 'acetolactate synthase, large subunit (ilvB-1) [Archaeoglobus fulgidus]' gi|7436703|pir||G69464 acetolactate synthase (EC 4.1.3.18) large chain - Archaeoglobus fulgidus gi|2648835|gb|AAB89531.1| '(AE000985) acetolactate synthase, large subunit (ilvB-1) [Archaeoglobus fulgidus]', score 513, E-value 1.00E-144.
  
 
 0.833
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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