STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LytBPenicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (288 aa)    
Predicted Functional Partners:
GcpE
Essential bacterial protein, involved in density-dependent regulation of peptidoglycan biosynthesis; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
 
 
 0.987
Cmk
Cytidylate kinase; Best Blastp hit = gi|585351|sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis], score 184, E-value 8.00E-46.
      0.983
RpsA
Ribosomal protein S1; Best Blastp hit = gi|7473661|pir||B75330 probable ribosomal protein S1 - Deinococcus radiodurans (strain R1) gi|6459772|gb|AAF11535.1|AE002036_6 '(AE002036) ribosomal protein S1, putative [Deinococcus radiodurans]', score 185, E-value 9.00E-46.
 
  
 0.980
IspA
Best Blastp hit = gi|7447349|pir||S74538 geranylgeranyl pyrophosphate synthase - Synechocystis sp. (strain PCC 6803) gi|1651762|dbj|BAA16690.1| (D90899) geranylgeranyl pyrophosphate synthase [Synechocystis sp.], score 273, E-value 2.00E-72; Belongs to the FPP/GGPP synthase family.
 
 
 0.936
IspD
4-diphosphocytidyl-2-methyl-D-erithritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
 
   
 0.857
IspF
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
 
   
 0.845
Dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
   
 0.844
IspE
4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
   
 0.827
TTE1349
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
       0.824
PlsC
1-acyl-sn-glycerol-3-phosphate acyltransferase; Best Blastp hit = gi|10174252|dbj|BAB05354.1| (AP001512) BH1635; unknown conserved protein [Bacillus halodurans], score 141, E-value 5.00E-33; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
       0.808
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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