STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HsdSRestriction endonuclease S subunits; Best Blastp hit = gi|2496187|sp|Q58926|YF31_METJA HYPOTHETICAL PROTEIN MJ1531 gi|2129334|pir||B64491 type I restriction enzyme CfrI specificity subunit homolog - Methanococcus jannaschii gi|1592162|gb|AAB99552.1| '(U67594) type I restriction-modification enzyme, S subunit, putative [Methanococcus jannaschii]', score 186, E-value 6.00E-46. (398 aa)    
Predicted Functional Partners:
HsdM
Type I restriction-modification system methyltransferase subunit; Best Blastp hit = gi|12519367|gb|AAG59530.1|AE005666_2 (AE005666) putative restriction modification enzyme M subunit (methylase) [Escherichia coli O157:H7 EDL933] gi|13364785|dbj|BAB38730.1| (AP002569) type I restriction modification enzyme M subunit [Escherichia coli O157:H7], score 282, E-value 6.00E-75.
 
 0.999
TTE0672
Predicted ATP-dependent endonuclease of the OLD family; Best Blastp hit = gi|9630369|ref|NP_046798.1| Old [Bacteriophage P2] gi|6136282|sp|P13520|VOLD_BPP2 OVERCOMING LYSOGENIZATION DEFECT PROTEIN gi|3139128|gb|AAD03309.1| (AF063097) Old [Bacteriophage P2], score 102, E-value 1.00E-20.
  
  
 0.799
TTE1546
Conserved hypothetical protein; Best Blastp hit = gi|10640020|emb|CAC11872.1| (AL445065) conserved hypothetical protein [Thermoplasma acidophilum], score 310, E-value 5.00E-83.
       0.773
AtpF
F0F1-type ATP synthase b subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
    
 
 0.665
TTE2665
Hypothetical protein.
  
    0.627
TopA
Topoisomerase IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superco [...]
 
   0.603
PolA
DNA polymerase I - 3'-5' exonuclease and polymerase domains; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.599
AprE
Subtilisin-like serine proteases; Best Blastp hit = gi|13540819|gb|AAK27733.1| (AY028704) thermicin [Thermoanaerobacter yonseii], score 810, E-value 0; Belongs to the peptidase S8 family.
     
 0.549
GlnQ
ABC-type polar amino acid transport system, ATPase component; Best Blastp hit = gi|11498288|ref|NP_069514.1| 'glutamine ABC transporter, ATP-binding protein (glnQ) [Archaeoglobus fulgidus]' gi|7442524|pir||H69334 glutamine transport protein glnQ - Archaeoglobus fulgidus gi|2649950|gb|AAB90561.1| '(AE001058) glutamine ABC transporter, ATP-binding protein (glnQ) [Archaeoglobus fulgidus]', score 342, E-value 4.00E-93.
      
 0.534
DnaA
ATPase involved in DNA replication initiation; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
      
 0.453
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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