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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NifSCysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Best Blastp hit = gi|13431585|sp|P57795|ISCS_METTE PROBABLE CYSTEINE DESULFURASE (NIFS PROTEIN HOMOLOG) gi|9887215|gb|AAG01802.1|AF276772_1 (AF276772) cysteine desulfurase NifS [Methanosarcina thermophila], score 358, E-value 9.00E-98. (391 aa)    
Predicted Functional Partners:
ThiI
Thiamine biosynthesis ATP pyrophosphatase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
 
 0.992
IscU
NifU homologs involved in Fe-S cluster formation; Best Blastp hit = gi|7387932|sp|O32163|NIFU_BACSU NIFU-LIKE PROTEIN gi|7427865|pir||E70019 nitrogen fixation protein nifU homolog yurV - Bacillus subtilis gi|2635764|emb|CAB15257.1| (Z99120) similar to NifU protein homolog [Bacillus subtilis], score 129, E-value 1.00E-29.
 0.987
SirA
Predicted Transcriptional regulator; Best Blastp hit = gi|2842585|sp|Q58397|Y990_METJA HYPOTHETICAL PROTEIN MJ0990 gi|2128042|pir||F64423 hypothetical protein homolog MJ0990 - Methanococcus jannaschii gi|1591652|gb|AAB98992.1| (U67541) conserved hypothetical protein [Methanococcus jannaschii], score 52, E-value 1.00E-06; Belongs to the sulfur carrier protein TusA family.
   
 0.976
NifS2
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
  
  
 
0.905
SelD
Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP.
    
 0.831
TTE1242
Predicted transcriptional regulator; Best Blastp hit = gi|10173875|dbj|BAB04978.1| (AP001511) BH1259; unknown conserved protein [Bacillus halodurans], score 134, E-value 6.00E-31.
 
  
 0.793
AcpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
    
 
 0.784
TTE1664
Conserved hypothetical protein.
  
    0.782
SirA2
Predicted Transcriptional regulator; Best Blastp hit = gi|13124657|sp|Q9X078|Y983_THEMA HYPOTHETICAL PROTEIN TM0983 gi|7449744|pir||D72310 conserved hypothetical protein - Thermotoga maritima (strain MSB8) gi|4981522|gb|AAD36062.1|AE001760_12 (AE001760) conserved hypothetical protein [Thermotoga maritima], score 80.9, E-value 2.00E-15; Belongs to the sulfur carrier protein TusA family.
   
 
 0.777
SirA3
Predicted Transcriptional regulator; Best Blastp hit = gi|11346752|pir||E81297 hypothetical protein Cj1505c [imported] - Campylobacter jejuni (strain NCTC 11168) gi|6968930|emb|CAB73926.1| (AL139078) hypothetical protein Cj1505c [Campylobacter jejuni], score 114, E-value 9.00E-25; Belongs to the sulfur carrier protein TusA family.
   
 
 0.777
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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