STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HtpX2Zn-dependent protease with chaperone function; Best Blastp hit = gi|6016282|sp|O58997|HTPX_PYRHO PROBABLE PROTEASE HTPX HOMOLOG gi|7441958|pir||C71070 probable heat shock protein - Pyrococcus horikoshii gi|3257674|dbj|BAA30357.1| (AP000005) 292aa long hypothetical heat shock protein [Pyrococcus horikoshii], score 213, E-value 3.00E-54; Belongs to the peptidase M48B family. (299 aa)    
Predicted Functional Partners:
LemA
Conserved hypothetical protein; Best Blastp hit = gi|13621592|gb|AAK33386.1| (AE006498) putative cytoplasmic membrane protein [Streptococcus pyogenes], score 190, E-value 1.00E-47.
 
    0.887
TrmA
SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase; Best Blastp hit = gi|10173301|dbj|BAB04406.1| (AP001509) RNA methyltransferase [Bacillus halodurans], score 257, E-value 2.00E-67; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
       0.625
DmpA2
L-aminopeptidase/D-esterase; Best Blastp hit = gi|7799513|emb|CAB90977.1| (AL355832) hypothetical protein SCE22.10 [Streptomyces coelicolor A3(2)], score 212, E-value 6.00E-54.
       0.610
TTE1792
Hypothetical protein.
       0.476
TTE1793
Conserved hypothetical protein; Best Blastp hit = gi|12514028|gb|AAG55359.1|AE005276_12 (AE005276) Z1214 gene product [Escherichia coli O157:H7 EDL933] gi|12514549|gb|AAG55769.1|AE005313_4 (AE005313) Z1654 gene product [Escherichia coli O157:H7 EDL933] gi|13360859|dbj|BAB34822.1| (AP002554) hypothetical protein [Escherichia coli O157:H7], score 60.8, E-value 7.00E-09.
       0.476
DnaJ
Molecular chaperones (contain C-terminal Zn finger domain); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-de [...]
  
 
 0.470
GrpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
  
  
 0.461
FliM
Flagellar motor switch protein; Best Blastp hit = gi|4426948|gb|AAD20622.1| (AF122909) flagellar switch protein FliM [Treponema denticola], score 273, E-value 3.00E-72.
    
   0.446
CinA
Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Best Blastp hit = gi|1842440|gb|AAB47708.1| (U87792) CinA [Bacillus subtilis], score 354, E-value 1.00E-96; Belongs to the CinA family.
       0.403
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.