STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
HisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)    
Predicted Functional Partners:
HisI
Phosphoribosyl-AMP cyclohydrolase; Best Blastp hit = gi|6175609|gb|AAF05095.1|AF150930_4 (AF150930) phosphoribosyl-AMP cyclohydrolase [Thermoanaerobacter ethanolicus], score 237, E-value 8.00E-62; In the C-terminal section; belongs to the PRA-PH family.
  
 0.999
HisF
Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.999
HisB
Best Blastp hit = gi|7387773|sp|O33564|HIS7_RHOSH IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (IGPD) gi|2398791|emb|CAA60712.1| (X87256) imidazoleglycerol-phosphate dehydratase [Rhodobacter sphaeroides], score 223, E-value 2.00E-57.
  
 0.999
HisG
ATP phosphoribosyltransferase (histidine biosynthesis); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
  
 0.999
HisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; Best Blastp hit = gi|6175607|gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus], score 186, E-value 3.00E-46.
 
  
 0.998
HisH
Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.998
HisC2
Best Blastp hit = gi|7450424|pir||E70478 histidinol-phosphate aminotransferase - Aquifex aeolicus gi|2984289|gb|AAC07813.1| (AE000771) histidinol-phosphate aminotransferase [Aquifex aeolicus], score 230, E-value 2.00E-59.
  
 0.998
HisS2
Histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
  
  
 0.991
HisC
Histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
 0.943
His2.2-2
Histidinol phosphatase and related hydrolases of the PHP family; Best Blastp hit = gi|7473516|pir||F75515 probable histidinol phosphatase - Deinococcus radiodurans (strain R1) gi|6458156|gb|AAF10049.1|AE001906_5 '(AE001906) histidinol phosphatase, putative [Deinococcus radiodurans]', score 144, E-value 1.00E-33; Belongs to the PHP hydrolase family. HisK subfamily.
  
 
 0.938
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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