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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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HisGATP phosphoribosyltransferase (histidine biosynthesis); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)    
Predicted Functional Partners:
HisI
Phosphoribosyl-AMP cyclohydrolase; Best Blastp hit = gi|6175609|gb|AAF05095.1|AF150930_4 (AF150930) phosphoribosyl-AMP cyclohydrolase [Thermoanaerobacter ethanolicus], score 237, E-value 8.00E-62; In the C-terminal section; belongs to the PRA-PH family.
 
 
 0.999
HisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.999
HisS2
Histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 0.999
HisF
Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.998
HisB
Best Blastp hit = gi|7387773|sp|O33564|HIS7_RHOSH IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (IGPD) gi|2398791|emb|CAA60712.1| (X87256) imidazoleglycerol-phosphate dehydratase [Rhodobacter sphaeroides], score 223, E-value 2.00E-57.
 
  
 0.998
HisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; Best Blastp hit = gi|6175607|gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus], score 186, E-value 3.00E-46.
 
  
 0.997
HisH
Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.997
HisC2
Best Blastp hit = gi|7450424|pir||E70478 histidinol-phosphate aminotransferase - Aquifex aeolicus gi|2984289|gb|AAC07813.1| (AE000771) histidinol-phosphate aminotransferase [Aquifex aeolicus], score 230, E-value 2.00E-59.
 
  
 0.983
HisS
Histidyl-tRNA synthetase; Best Blastp hit = gi|7674351|sp|Q9X0H5|SYH_THEMA HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS) gi|7437817|pir||A72298 histidine--tRNA ligase (EC 6.1.1.21) - Thermotoga maritima (strain MSB8) gi|4981634|gb|AAD36166.1|AE001768_15 (AE001768) histidyl-tRNA synthetase [Thermotoga maritima], score 400, E-value 1.00E-110.
 
 
 0.915
HisC
Histidinol-phosphate aminotransferase/Tyrosine aminotransferase; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
  
 0.863
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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