STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GlmSGlucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa)    
Predicted Functional Partners:
CpsG2
Phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
 
 0.980
ManA
Phosphomannose isomerase; Best Blastp hit = gi|13249157|gb|AAK16707.1| (AF324506) mannose-6-phosphate isomerase [Bacillus subtilis], score 211, E-value 8.00E-54.
  
 
 0.954
GlmU
Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.
  
 0.950
CarB
Carbamoylphosphate synthase large subunit (split gene in MJ); Best Blastp hit = gi|1168772|sp|P46537|CARB_BACCL 'CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHAIN (CARBAMOYL-PHOSPHATE SYNTHETASE AMMONIA CHAIN)' gi|2118367|pir||I40169 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) - Bacillus caldolyticus gi|312443|emb|CAA51739.1| (X73308) carbamoyl-phosphate synthase (glutamine-hydrolysing) [Bacillus caldolyticus], score 1146, E-value 0.
   
 0.938
NagA
N-acetylglucosamine-6-phosphate deacetylase; Best Blastp hit = gi|10173034|dbj|BAB04140.1| (AP001508) N-acetylglucosamine-6-phosphate deacetylase [Bacillus halodurans], score 316, E-value 3.00E-85.
   
 0.934
NagB
6-phosphogluconolactonase/Glucosamine-6- phosphate isomerase/deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
  
 
 0.934
Pgi
Glucose-6-phosphate isomerase; Best Blastp hit = gi|120717|sp|P13375|G6PA_BACST GLUCOSE-6-PHOSPHATE ISOMERASE A (GPI A) (PHOSPHOGLUCOSE ISOMERASE A) (PGI-A) gi|68452|pir||NUBSSA glucose-6-phosphate isomerase (EC 5.3.1.9) A [validated] - Bacillus stearothermophilus gi|40046|emb|CAA34634.1| (X16639) phosphoglucose isomerase A (AA 1-449) [Bacillus stearothermophilus], score 617, E-value 1.00E-176.
  
 
 0.932
PurL
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interac [...]
    
 0.920
PurF
Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
    
0.919
CarA
Carbamoylphosphate synthase small subunit; Best Blastp hit = gi|1705597|sp|P52557|CARA_BACCL 'CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, SMALL CHAIN (CARBAMOYL-PHOSPHATE SYNTHETASE GLUTAMINE CHAIN)' gi|2126769|pir||I40168 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) - Bacillus caldolyticus gi|312442|emb|CAA51738.1| (X73308) carbamoyl-phosphate synthase (glutamine-hydrolysing) [Bacillus caldolyticus], score 381, E-value 1.00E-105; Belongs to the CarA family.
    
 0.916
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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