STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TrmU2tRNA-specific 2-thiouridylase MnmA 2; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (364 aa)    
Predicted Functional Partners:
TrmU
tRNA-specific 2-thiouridylase MnmA 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
  
  
 
0.901
NifS2
Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
 
  
 0.856
MetG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.620
ZntA
Cation transport ATPases; Best Blastp hit = gi|7531047|sp|O32220|ATCU_BACSU POTENTIAL COPPER-TRANSPORTING ATPASE gi|7428307|pir||E70041 probable copper-transporting ATPase (EC 3.6.1.-) yvgX - Bacillus subtilis gi|2635863|emb|CAB15355.1| (Z99121) similar to heavy metal-transporting ATPase [Bacillus subtilis], score 838, E-value 0.
       0.598
Sun
tRNA and rRNA cytosine-C5-methylases; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.534
TTE2462
Conserved hypothetical protein; Best Blastp hit = gi|11497958|ref|NP_069182.1| mercuric transport protein periplasmic component (merP) [Archaeoglobus fulgidus] gi|7483865|pir||B69293 mercuric transport protein periplasmic component (merP) homolog - Archaeoglobus fulgidus gi|2650285|gb|AAB90886.1| (AE001080) mercuric transport protein periplasmic component (merP) [Archaeoglobus fulgidus], score 49.7, E-value 7.00E-06.
       0.522
MesJ3
Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
 
 
 0.513
ThdF
Predicted GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
 
 
 0.511
PheT
Best Blastp hit = gi|3123292|sp|P17922|SYFB_BACSU PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA LIGASE BETA CHAIN) (PHERS) gi|7428487|pir||YFBSB phenylalanine--tRNA ligase (EC 6.1.1.20) beta chain - Bacillus subtilis gi|1770031|emb|CAA99564.1| (Z75208) phenylalanyl-tRNA synthetase beta subunit [Bacillus subtilis] gi|2635328|emb|CAB14823.1| (Z99118) phenylalanyl-tRNA synthetase (beta subunit) [Bacillus subtilis], score 591, E-value 1.00E-167.
  
  
 0.507
CinA
Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Best Blastp hit = gi|1842440|gb|AAB47708.1| (U87792) CinA [Bacillus subtilis], score 354, E-value 1.00E-96; Belongs to the CinA family.
  
    0.495
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.