Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZntA2Cation transport ATPases; Best Blastp hit = gi|7436386|pir||D70041 heavy metal-transporting ATPase homolog yvgW - Bacillus subtilis gi|2635862|emb|CAB15354.1| (Z99121) similar to heavy metal-transporting ATPase [Bacillus subtilis], score 688, E-value 0. (658 aa)    
Predicted Functional Partners:
ArsR
Predicted Transcriptional regulator; Best Blastp hit = gi|7474029|pir||A75601 transcription repressor SmtB - Deinococcus radiodurans (strain R1) gi|6460539|gb|AAF12245.1|AE001862_71 (AE001862) transcriptional repressor SmtB [Deinococcus radiodurans], score 120, E-value 8.00E-27.
 
  
 0.984
CopZ
Copper chaperone; Best Blastp hit = gi|13702508|dbj|BAB43649.1| '(AP003137) ORFID:SA2345; hypothetical protein, similar to mercuric ion-binding protein [Staphylococcus aureus]' gi|13874260|dbj|BAB44800.1| (AP003365) hypothetical protein [Staphylococcus aureus], score 73.9, E-value 2.00E-13.
 
 
 0.969
GrxC
Glutaredoxin and related proteins; Best Blastp hit = gi|7451278|pir||F72303 glutaredoxin - Thermotoga maritima (strain MSB8) gi|4981572|gb|AAD36108.1|AE001764_11 (AE001764) glutaredoxin [Thermotoga maritima], score 90.9, E-value 1.00E-17.
  
 
 0.640
TTE2469
Hypothetical protein.
       0.484
MesJ4
Predicted ATPase of the PP-loop superfamily implicated in cell cycle control; Best Blastp hit = gi|7429999|pir||E70415 conserved hypothetical protein aq_1333 - Aquifex aeolicus gi|2983761|gb|AAC07321.1| (AE000735) hypothetical protein [Aquifex aeolicus], score 273, E-value 2.00E-72; Belongs to the TtcA family.
       0.484
PorA
Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit; Best Blastp hit = gi|4972241|emb|CAB43935.1| (Y17727) pyruvate ferredoxin oxidoreductase [Clostridium pasteurianum], score 1671, E-value 0; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
  
  
 0.444
Ada
Methylated DNA-protein cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
 
   
 0.401
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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